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The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained

The syringe is inserted into the glass container and filled to the desired amount for proper dosing

Good levels of vitamin b12 in body relates to wellbeing of gut

Magnesium shares absorption pathways in the gut and can bind to certain drugs, rendering them ineffective

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