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In order to gain insights into biological pathways associated with increasing emphysema severity within a patient and explore computational strategies for identifying COPD therapeutics, we obtained paired samples from eight regions at regular intervals between the apex and base of each explanted lung from six patients with severe COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage IV) and two donor lungs

Scand J Rheumatol (1997) 26:3017

The L-ornithine L-aspartate is a salt which combines ornithine aminoacids and L-aspartic acid

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Zinc, an essential mineral, enhances immune system functionality and promotes healthy cellular activity