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Spring 2026 is an ideal time to consult, as patients who began GLP-1 medications in late 2025 are now approaching stable weights and can plan body contouring with sufficient recovery time before summer

Its mechanism is broader than therapies that target single or dual receptor pathways, offering a more comprehensive approach to metabolic regulation

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Rushing from 1mg to 8mg or 12mg over just a few weeks creates an adaptation crisis

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In HEK293 cells expressing human GIP receptor or GLP-1 receptor, tirzepatide potently stimulated cAMP accumulation by both receptors, and the potency of tirzepatide was similar to that of native GIP and approximately 13-fold weaker than that of GLP-1 in these assays [88]