While existing reviews primarily focus on carnitine-lipid metabolism relationships, comprehensive analyses detailing its molecular roles across the MASLD spectrum remain limited
It has been demonstrated to suppress the expression of SREBP-1c and FAS, key regulators of lipogenesis, while simultaneously promoting fatty acid oxidation through upregulation of peroxisome proliferator-activated receptors (PPARs)
In addition, inhibiting the expression of SLC7A11 gene will affect the synthesis of glutathione, thereby causing the apoptosis of IDH1 mutant glioma cells
Mechanisms of Ferroptosis and Relations with Regulated Cell Death: A Review
J.SchupfN.LuchsingerJ
Less frequent AEs like hypoglycemia, is mostly seen in combination with insulin or sulfonylureas (157) and some reports of pancreatobiliary complications are partially explained by direct altered absorption of bile acids, rapid weight loss or changes in the gallbladder motility with increased risk of pancreatitis, even though it is extremely rare (160)