To ensure the groups were comparable, the team matched each patient taking GLP-1 medications to a patient not taking these medications, based on similar age, sex, and other factors
In December 2025, the Centers for Medicare & Medicaid Services introduced the BALANCE (Better Approaches to Lifestyle and Nutrition for Comprehensive hEalth) Model
However, pharmacovigilance reporting in public databases is subject to many major limitations, such as heterogeneous reporting, including notoriety and ripple bias, double reporting, the lack of a population denominator or enough clinical detail to enable comparison between agents and over time [20, 22], therefore no causal association link can be inferred from such studies
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