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Mice exposed to altered light-dark cycles also exhibited disrupted Per2 rhythms alongside chronic inflammation characterized by elevated IL-1, IL-6, and TNF-, and changes in macrophage populations favoring pro-inflammatory phenotypes 126,202

Since changes in are suppressed at the level of Hcy, examining the methionine cycle in greater detail holds the key to understanding the discrepancy between the predictions of the remethylation block hypothesis and the Reed-Nijhout model