Dercums first patient was a woman with obesity with fat similar to a woman with Stage 3 lipedema (221)
Start with tirzepatide monotherapy, titrate to therapeutic dose (12.515mg weekly), allow 1620 weeks to reach plateau, then reassess
however, RB1 loss leads to excessive E2F1 activation, resulting in uncontrolled BNIP3 expression and autophagic cell death under hypoxic or nutrient-deprived conditions
Key Takeaway: Glutathione's impact on hair is primarily protective
15 Transplanted hairs typically shed within the first few weeks (an expected part of the process), with new growth beginning around month 34 and full, mature results visible at 912 months
Significant weight loss usually occurs within 3 to 6 months , with maximum benefits seen after one year of consistent use