Furthermore, a notable rise in the expression levels of genes associated with autophagy, as well as a higher quantity of autophagic vacuoles and lysosomes, has been detected in degenerated intervertebral discs and the annulus fibrosus (181, 182)
Fibrogenesis Tissue Repair 5:11
COG/KOG VS GO VS KEGG: SELECTING THE RIGHT FUNCTIONAL ANNOTATION STRATEGY Understanding the relative strengths and limitations of the COG KOG database, Gene Ontology analysis, and KEGG pathway enrichment is essential for selecting appropriate functional annotation strategies
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doi: 10.1016/j.mito.2017.07.002
found that accumulation of iron and ROS, dysfunction of iron metabolism, decreased GPX4 activity, and mitochondrial atrophy after TBI are all typical characteristics of ferroptosis