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The role of IRE1 in cell fate decisions Ire1 is the only major UPR sensor that is present in budding yeast, plants, and metazoans, and is often referred to as the most conserved UPR branch (Hollien 2013)

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ROS directly cause lung damage as a result of DNA, lipid, carbohydrate, and protein alterations, and activate local inflammatory responses that contribute to COPD development and progression (7983)

The effective concentrations are remarkably low