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A properly supervised titration starts low and increases gradually based on how the individual responds

General Tips for Managing GLP-1 medications Side Effects Gradual Dose Adjustment: Start with a low dose and increase gradually as recommended by your doctor

Early phase 2 clinical data, including a 2023 publication in the New England Journal of Medicine , suggest retatrutide may produce substantial weight loss

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A landmark clinical trial of semaglutide, published in 2021, found that participants experienced an average of 15% weight loss over the course of 68 weeks while those on placebo lost 2%

Soresi and Giannitrapani, 2024)