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2021;5(1):e10405
Synergistic enhancement of topotecan-induced cell death by ascorbic acid in human breast MCF-7 tumor cells
2.2 Restricting the recruitment and localization of TAMs Macrophages enter tumors under the action of a variety of chemokines, such as CC motif chemokine 2 (CCL2), CCL3, CCL4, CCL5, colony-stimulating factor-1, and vascular endothelial growth factor (VEGF), based on this the strategy of targeting TAMs to treat tumors can also block TAMs entry into tumors by targeting these chemokines that recruit macrophages (12)
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