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Given its role in catalyzing the conversion of pyruvate to lactate in glycolytic cancer cells and the observation that LDHA deficiency results in only relatively mild symptoms, such as exertional myopathy, LDHA represents a pivotal and safe therapeutic target (150,167)
If you think you're administering a 500mcg dose but your concentration is off by 20%, your results are immediately invalid
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This gap in knowledge is why regulatory guidance advises against use during lactation, even though documented harm has not been reported