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This variation is associated with reduced MC1R receptor function, which may decrease signaling efficiency through this part of the melanocortin pathway

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Junction PCR confirmed the knock-in event in the liver, and digital PCR indicated an efficiency of approximately 1% for a single administration of Donor+Cas9, consistent with previously reported in vivo knock-in efficiencies (Fig

If it is too low, or if you appear dehydrated, the staff may ask you to return another day for your own protection