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It is important to understand the eligible US population that could benefit from such therapy, its potential impact on the US population-wide prevalence of overweight/obesity, as well as the potential benefits on CVD outcomes

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Methods Enzymol 77:237253 Lieberman MW, Wiseman AL, Shi ZZ, Carter BZ, Barrios R, Ou CN, Chevez-Barrios P, Wang Y, Habib GM, Goodman JC, Huang SL, Lebovitz RM, Matzuk MM (1996) Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice

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In certain embodiments, an otic formulation or composition comprising a dye or other tracer compound eliminates the need for invasive procedures that are currently used in animal models to monitor the concentrations of drugs in the endolymph and/or perilymph