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This could happen if the treatment and control groups are not comparable- for example if doctors prescribed GLP-1s vs another diabetes medication for systematic reasons such as the health profile of the patient

It was hoped that the drug would offer improved weight loss for patients with diabetes, who typically have a tougher time shedding pounds on existing GLP-1 treatments, but the 15.7% weight reduction result from the REDEFINE-2 trial disappointed

A 2016 review by Sikiric and colleagues in Current Neuropharmacology framed BPC-157's effects within a brain-gut axis model, while a 2024 review by Sikiric and colleagues in Pharmaceuticals (Basel) examined the peptide's relationships with multiple neurotransmitter systems

& Wakelam, M

These studies demonstrate that allulose has a protective effect on hepatic outcomes derivative of a Western diet

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