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Acknowledgements This study was supported by National Key Research and Development Plan Precision Medicine Research (2017YFSF090203), the National Natural Science Foundation of China (81470840, 81873565 and 81800510), Shanghai Sailing Program (18YF1415900), VA Merit Award (I01BX004033 and I01BX001390), and Research Career Scientist Award (IK6BX004477)

More serious deficiencies have the potential to impair heart and neurological function, leading to a wide range of serious symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia and changes in reflexes

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Our cells need B12 to create DNA and to aid the metabolism of fats and proteins in the body

ETS1 (Cell Signaling Technology, Danvers, MA, #14069)