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Retatrutide is called a triple agonist because it activates three hormone receptors: GLP-1, GIP and glucagon

This example underscores a broader point: not all underexplored peptides need to become drugs to influence drug discovery

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Eating slowly gives your GLP-1 levels a chance to rise before you reach for seconds

However, in rats with diet-induced obesity, GLP-1 secretion in respond to glucose stimulation is significantly impaired [14]

Retatrutide is currently under investigation across six therapeutic research areas: obesity, type 2 diabetes, knee osteoarthritis, obstructive sleep apnoea, chronic low back pain, and metabolic dysfunction-associated steatotic liver disease, a breadth of scientific application that drives multi-protocol demand across research institutions worldwide