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Because the peptide activates GLP-1R, GIPR, and GCGR within a single molecular framework, it allows researchers to study how coordinated receptor signaling influences food intake pathways, lipid mobilization, and whole-body energy balance in controlled models

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Most of the anti-inflammatory effects of the PPARs act by inhibiting NF-B and activator protein (AP)-1, which ultimately repress the expression of downstream genes like PTGS2, inducible nitric oxide synthase (iNOS), IL-6, and IL-12 that are involved in the inflammatory responses 58

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