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N Engl J Med 2016, 375(4): 311-322

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We know that on average, for every 1kg people lost whilst on Wegovy, approximately 0.3kg was muscle, and 0.7kg was fat

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In contrast, induction of ER stress via central administration of thapsigargin completely abolished the RYGB-mediated improvement in leptin sensitivity, without affecting control animals, highlighting ER stress as a key regulatory factor in the beneficial effects of RYGB on hypothalamic leptin signaling [97]