Chronic hypoxia drives the conversion of Tregs to pro-inflammatory Th17 cells via the HIF-1 pathway, characterized by reduced CD25 expression, increased OX40 expression, and exhaustion of immunosuppressive function, which exacerbates Th1/Th17 cell polarization and the release of pro-inflammatory factors such as IL-17A and IFN- (Lantz et al., 2024)
C.MclachlanJ
Early-life nutritional exposures and lifelong health: immediate and long-lasting impacts of probiotics, vitamin D, and breastfeeding
Lecanemab, approved by the Food and Drug Administration last year, and donanemab, out earlier this month, are both antibody treatments built around the idea that reducing the presence of key amyloid plaques in the brain will help slow dementia progression
Biochemistry of microbial itaconic acid production
This was also the first study having investigated a PET tracer targeting the GCGR in humans