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CDCA, CA, DCA, and LCA are all FXR agonists that can activate the FXR-CYP7A1 signaling pathway (80), which inhibits cholesterol consumption and causes abnormal cholesterol levels

The sixth is cardiometabolic indication expansion

A separate subsection covers rare reports of serious regurgitant cardiac valvular disease

The reduction of these disulfide bonds results in oxidation of thioredoxin which then is reduced by thioredoxin reductase