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Aside from vitamin K, which has a low potential for toxicity, the remaining three fat-soluble vitamins have a set UL due to their potential to cause harm at high doses

In preclinical models resistant to anti-PD-L1 treatment, dual blockade of IL-6R and PD-L1 attenuated tumour growth and improved survival [350, 351], leading to clinical evaluation of this combination therapy

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The resulting strain W303-1b/gsh1/F (F pathway) together with W303-1b/G (G pathway) and W303-1b/gsh1/pro1 (P pathway) represent different pathway strains (Table 2)

This is crucial for optimal oxygen delivery throughout the body