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This pharmacokinetic profile, combined with its amphiphilic character (allowing it to cross the blood-brain barrier), has sustained interest in DSIP as both a research tool and a subject of investigation in its own right

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J Biol Chem 277:4350511 Okamoto T, Akaike T, Sawa T, Miyamoto Y, van der Vliet A, Maeda H (2001) Activation of matrix metalloproteinases by peroxynitrite-induced protein S -glutathiolation via disulfide S -oxide formation

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