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Therefore, rigorously controlled trials with sufficient blinding and larger cohorts are needed to determine whether GFCF diets have a genuine impact on ASD symptoms (Figure 2)

CoA is a cofactor in more than 70 enzymatic pathways including: Amino acid catabolism Acetylcholine synthesis Carbohydrate metabolism Fatty acid oxidation Heme synthesis Pyruvate degradation Phase II detox acetylation CoA is also involved in the initial steps of cholesterol synthesis and all the downstream metabolites of cholesterol including steroids, Vitamin D, and bile acids

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