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Diet control, moderate exercise, behavior modification programs, bariatric surgery and prescription drug treatment are the major interventions used to help people lose weight

Efficacy and safety of liraglutide versus placebo as add-on to glucose-lowering therapy in patients with type 2 diabetes and moderate renal impairment (LIRA-RENAL): a randomized clinical trial

In theory, this could make the transition smoother for GI effects related to GLP-1 and GIP, while the glucagon-mediated effects (thermogenesis, increased heart rate) would be entirely new

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Bhatt DL, Szarek M, Pitt B, et al

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