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[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Packer M, Anker SD, Butler J, Filippatos G, Zannad F

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In line with our short-term metabolic analyses, previous studies in New Zealand obese and diet-induced obese male mice suggested that GLP1/E acts primarily at central levels to reverse metabolic alterations by decreasing food intake and body weight, while the potential beneficial effects on pancreatic beta-cells were possibly secondary and indirectly-mediated 33,48

In one study, subjects who took 1.5 grams a day of ALC for 10 weeks scored better on a scale that measured frailty and improved grip strength