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HIF-PHI, such as roxadustat and vadadustat, have revolutionized renal anemia management by stimulating endogenous erythropoietin (EPO) and improving iron utilization

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Role of gut-liver axis Cirrhosis is associated with dramatic alterations of the gut microbiome [64], which likely contribute to CHE pathogenesis via disruption of the gut-liver-brain axis

Overall, combination therapy with GLP-1RA plus SGLT2i was associated with better clinical outcomes of MASLD, compared to SGLT2i monotherapy