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Piel RB, Dailey HA, Medlock AE (2019) The mitochondrial heme metabolon: insights into the complex(ity) of heme synthesis and distribution

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This is very much still a work in progress, Cogswell said adding that critiques about the accessibility of the location were valid

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Such de novo synthesis is obligatory to compensate for catabolism of glutamate and GABA related to oxidative metabolism when the amino acids are used as energy substrates