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While DOPAL is a natural intermediate in the catabolism of dopamine, it has been shown to have neurotoxic effects

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By age 50, the regeneration process has slowed to every nine weeks

Notably, lumateperone, an antagonist for D1, D2, D4, and serotonin receptor 2A and transporters (Kumar et al., 2018), improved depressive symptoms in bipolar depression patients in the first clinical trials (Calabrese et al., 2021), although it also showed potential inflammatory effects (El-Haroun et al., 2021)