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Patients with higher GLP-1R expression typically experience more noticeable hunger rebounds after a missed dose, while those with lower sensitivity may tolerate brief gaps more easilyuseful insight for staying motivated about consistency

(Primary completion November 2025, 68-week treatment period, 4mg/9mg/12mg dose arms

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Fralick M, Schneeweiss S, Patorno E (2017) Risk of diabetic ketoacidosis after initiation of an SGLT2 inhibitor