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Figure 1 4 Clinical evidence of GLP-1R agonists in managing DPN Unlike preclinical evidence, studies investigating the effect of GLP-1R on DPN are quite rare

In parallel, SSRIs exert therapeutic their effect by occupying 80% of 5-HTT (Meyer et al., 2007) and provides the rational that the monoamine systems are resilient and require significant alterations in their function to produce clinically relevant effects (Blier, 2008)

Furthermore, the co-administration of peptides also enhanced the systemic levels of human growth hormone, enabling systemic delivery by creating transient openings in the skin [55]

The trial is a randomized, double-blind, placebo-controlled multicenter study to evaluate the safety, tolerability, pharmacokinetics, and weight loss efficacy

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