GHK-Cu is most commonly associated with skincare products, but copper peptides are increasingly being incorporated into scalp-focused formulations and modern haircare products
Oxidative stress: role and response of short guanine tracts at genomic locations
In CB1R knockout mice, an accelerated aging phenotype has been reported
doi: 10.3390/biom10101367 75 FinneyJ.MoonH.-J.RonnebaumT.LantzM.MureM
Notably, because of reduced lipidation and diminished affinity of ApoE4 for TREM2, ApoE4 has the potential to impede homeostatic microglial functions in comparison to other isoforms
What they found (summary): Amylin is a critical partner of insulin in metabolism, the loss of amylin in T2DM is as significant as the loss of insulin The AMY1 receptor in the area postrema is the primary target for the appetite effect Amyloid aggregation is the main problem with native amylin, proline substitutions (the Pramlintide strategy) are essential The half-life of native amylin is only 13 minutes, that is why lipidated analogs like Cagrilintide are necessary Perspective: amylin + GLP-1 combinations are the natural evolution of metabolic pharmacotherapy Why it matters: This is the reference article for amylin pharmacology
