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GHRH receptor activation and GHS-R1a activation engage distinct intracellular signaling cascades cAMP/PKA and IP3/calcium mobilization pathways respectively that converge at the level of GH vesicle exocytosis to produce a synergistically amplified secretory response

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However, human studies often show associations between senescence and endometriosis, rather than proving causality, and small, heterogeneous cohorts limit the applicability of the findings

Mrp4-knockout mice, which are established and repeatedly backcrossed to the C57BL/6J mice