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Due to species differences, dulaglutide (a human GLP-1 variant fused with a human IgG4 variant) showed a longer t 1/2 in humans than in monkeys (120 h versus 51.6 3.2 h, respectively) and further research will be required to determine whether Exendin-4-Fc also has a longer t 1/2 in humans

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Does not engage the GH receptor's growth-promoting / glucose pathways in the same manner as intact GH

human relevance is unknown, but patients should be advised to seek medical attention for symptoms like a lump in the neck or persistent hoarseness Diabetic retinopathy complications : Rapid glucose improvement may temporarily worsen retinopathy in diabetic patients Special considerations for perimenopausal women include: Pregnancy planning : Stop semaglutide at least 2 months before planned pregnancy

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