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It has been suggested that the FDA-approved dose of 50 mg daily is not sufficient to stimulate human BAT due to low 3-adrenergic receptor expression in human supraclavicular BAT and the effect seen with high doses of mirabegron are instead due to 2-adrenergic receptor agonism [149]

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Viability screens are the normalizing control for proliferation, apoptosis, and pathway-level readouts

Table 1 summarizes the key characteristics, advantages, and limitations of AD, VaD, and MD models, emphasizing how each model recapitulates aspects of neurodegeneration and vascular pathology

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