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Why High Doses Matter The risk of acne is more commonly linked to taking high doses of vitamin B12

Use of CSII is associated with improvement in quality of life, particularly in areas related to fear of hypoglycemia and diabetes distress, compared with multiple daily injections of insulin (16,17)

doi: 10.1016/j.dld.2009.08.002

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Far stronger, by the article's own table, which rates GLP-1 medications as having strong randomized controlled trial evidence for weight loss and cardiovascular outcomes and marks their evidence gap as none