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Pathway enrichment analysis was performed by using Metaboanalyst 5.0

Metabolism 53(53):297302 Turk H, Sevinc A, Camci C, Cigli A, Buyukberber S, Savli H, Bayraktar N (2002) Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus

Thats why drugs like GLP-1 agonists have gained popularity for their appetite-suppressing effects, with their use increasing by 111% in the United States between 2020 and 2022

In vitro and in vivo, Rho-kinase 2 (ROCK-II) activates smooth muscle in the corpus cavernosum, and ROCK-II inhibitors relax smooth muscles, so Mucuna pruriens seed extracts that inhibit this process may prove useful for treating ED

Restoring balance at this level supports steady, science-backed improvements

Acknowledgements We appreciated the participants and their families and all academic personnel of the Imam Reza Hospital and the Mashhad University of Medical Sciences, Mashhad, Iran, for their kind cooperation