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PPIs are typically tried for 48 weeks with review and step-down to the lowest effective dose or on-demand therapy

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This suggests that unlike the Rho kinase inhibitor Y-27632, that enhances RBC deformation and raises the release of low O 2 tension-induced ATP, simvastatin blocks low O 2 tension-induced ATP release through uncoupling RBC deformation and low O 2 tension-induced release of ATP

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If GI side effects on Mounjaro are the reason youre considering a switch, CagriSema may not solve that

This will help them adjust your treatment plan if necessary and provide additional advice on managing side effects