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Ginsenoside Rg1 downregulates calpain-1 to inhibit STAT3 phosphorylation, blocks the IL-6/STAT3 inflammatory pathway and the release of inflammatory factors, and can inhibit the activation of the TXNIP/NLRP3 inflammasome, reducing IL-1 secretion (Zhang R

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doi: 10.3390/vaccines4030028 96 DinarelloCA

Thus, NRF2-addicted cancers adopt highly specialized metabolism favoring glutathione synthesis that is essential for the potent anti-oxidant and detoxification capacities, which cannot be achieved by a simple activation of NRF2

Mater 32 (10), 1905823