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Pharmacokinetics Half-life : ~7 days supports once-weekly dosing Peak plasma concentration : Reached in 13 days post-injection Metabolism : Proteolytic cleavage and -oxidation of fatty acid side chain Excretion : Primarily via urine and feces

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Park H, DiNatale D, Chung M, Park Y, Lee J, Koo S, Park HJ, DiNatale DA, Chung M-Y, Park Y-K, Lee J-Y, Koo SI, OConnor M, Manautou JE, Bruno RS, Bruno R (2011) Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice

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Lilly Scores FDA Approval in Obstructive Sleep Apnea Afflicting more than 1 billion people worldwide, obstructive sleep apnea (OSA) is one of the most common breathing-related sleep disorders, though most cases are either undiagnosed or untreated