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The American Diabetes Association (ADA) recommends GLP-1 receptor agonists with proven cardiovascular benefit as preferred agents for patients with type 2 diabetes who have established atherosclerotic cardiovascular disease or indicators of high cardiovascular risk

Two possible explanations were proposed

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Some protocols recommend taking it on an empty stomach, first thing in the morning, to maximize absorption and align with the natural fasting state when lipolysis is already elevated

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The ongoing development of triple agonists, oral formulations, and personalized medicine approaches builds on this foundation to create even more effective treatment options