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MarketSizing and Forecasting: A hybrid model combining topdown therapeutic demand forecasts with bottomup drug sales and usage data was used

This intricate nexus, predominantly involving peripherally activated immune cells, notably circulating monocytes, and microglia, along with its repercussions on signaling pathways like serotonin, dopamine, and corticotropin-releasing hormone, with the latters implications on the hypothalamus-pituitaryadrenal axis, initiates sickness behaviors, including fatigue (4, 8)

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References: Office of Dietary Supplements, National Institutes of Health

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