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The dual mechanism is not incremental

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Ten of the 11 letters also cite public health concerns resulting from the promotional communications, stating they create a misleading impression about the safety and efficacy of the product

Second, head-to-head comparative trials between GLP-1 RA monotherapy, dual agonists, and triple agonists in MASH populations with histological endpoints are entirely lacking: current selection among agents relies on indirect comparisons across trials with different inclusion criteria and follow-up periods