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T-cell surface molecules or secreted factors may also regulate the expression of lipid-metabolic enzymes such as ACSL4, thereby indirectly fostering ferroptosis (113)

A 2023 safety review of probiotics highlighted theoretical and documented risks, including bacteremia or fungemia in high-risk patients, immune dysregulation, and the potential for horizontal transfer of antimicrobial resistance or virulence genes within the gut ecosystem (525)

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