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(2015) genotyped 609 cases and 106 controls in a multicenter, casecontrol study

In the acute window (024 h) the priority is to contain ROS spikes (e.g., ischemiareperfusion, SIRS) by attenuating the source (NOX/mitochondrial bursts), buffering at the compartment of origin (mitochondria, ER, endothelium) and controlling free metals that license Fenton chemistry