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Persistent bruising suggests either a technique issue (angle, depth, or pressure) or an underlying condition affecting blood vessels or clotting

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NO-S: Data curation, Investigation, Writing review and editing

The remaining missing data were subjected to kNN imputation, as this method has been proven to provide better performance, robustness, and an overall marginal type 1 error rate [30, 31], especially when the proportion of missing data across samples for a molecular feature is relatively low (as in our datasets, with only 11.6% of imputable variables)

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