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If your A1C is more than 1.5 percent above your target, a combination medication therapy is now the most common strategy per the standards of the American Diabetes Association. Combination medication therapy means taking more than one diabetes drug at once

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That can lead to immediate side-effects including: Nausea and vomiting Diarrhea Constipation and abdominal pain Bloating Dizziness Fatigue This is a fairly common laundry list of the sort of side effects you get when you are messing around with the human digestive system