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The adverse effects of GLP-1RA, such as nausea, constipation, and diarrhea, are thought to be the result of the pharmacological action of GLP-1, but the mechanisms have not been fully elucidated
153,154 Studies have shown that activating GLP-1R leads to a decrease in pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-) in adipose tissue, revealing a systemic anti-inflammatory impact
The logic is straightforward: you're about to create a significant demand for energy
More infrequent, rare or serious side effects have also been reported, including low blood sugar, lung aspiration, thyroid cancer and gallstones
It is synthesised in the body from the amino acids lysine and methionine, primarily in the liver and kidneys, and is also obtained through dietary sources such as red meat, fish, and dairy products
They also slow gastric emptying, prolonging the sensation of fullness after meals, and act on appetite centres in the brain to reduce hunger and food intake
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