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No Phase I, II, or III trial has been completed and published in a peer-reviewed journal with systematic adverse-event reporting

Prez R, Castilla-Cortzar I, Nez M, Prado A, Mirpuri E, Garca M, Gonzlez Barn S, Picardi A: IGF-I does not improve fat malabsorption in cirrhotic rats

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Blood levels peak around age 20 at approximately 200 ng/mL and decline to roughly 80 ng/mL by age 60, correlating with diminished skin elasticity and regenerative capacity