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GLP-1 agonists promote satiety, delay gastric emptying and reduce hunger signals, making it easier to maintain a caloric deficit

The FDA label specifically notes that dose escalation can be delayed or the dose maintained at a lower level if gastrointestinal side effects occur

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Weight Regain Timeline and Metabolic Changes After Stopping Clinical data shows that approximately 50-70% of weight lost on GLP-1 therapy returns within 12 months of discontinuation, though this range varies widely based on lifestyle adherence and genetic factors

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